Diagnostic Pathology Cytopathology

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners and trainees at all levels of experience and training. Covering all aspects of cytology, including gynecologic, nongynecologic exfoliative, fine-needle aspiration, and imaging, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Cytopathology is a visually stunning, one-stop resource for every practicing pathologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource.

Mody, Thrall & Krishnamurthy

Table of Contents

Part I: Gynecologic Cytopathology
SECTION 1: OVERVIEW

4 Pap Test and Cervical Cancer Screening: History and Reporting Terminology
Nikolaos Chantziantoniou, PhD, ART(CSMLS), CFIAC and Dina R. Mody, MD
8 Cytopreparation, Instrumentation, and Automated Screening in Gynecologic Cytology
Michael J. Thrall, MD and Debora A. Smith, CT(ASCP)
10 Specimen Adequacy in Cervicovaginal Cytology
Dina R. Mody, MD and George G. Birdsong, MD

SECTION 2: BENIGN AND INFECTIOUS CONDITIONS

14 Normal Pap Test Nikolaos Chantziantoniou, PhD, ART(CSMLS), CFIAC and Dina R. Mody, MD
16 Infectious and Other Organisms in Pap Tests Nikolaos Chantziantoniou, PhD, ART(CSMLS), CFIAC and Dina R. Mody, MD
18 Nonneoplastic Findings, Mimics, and Artifacts
Ekene I. Okoye, MD and Dina R. Mody, MD

SECTION 3: SQUAMOUS CELLABNORMALITIES AND MIMICS

28 Low-Grade Squamous Intraepithelial Lesion and Mimics
Dina R. Mody, MD
30 High-Grade Squamous Intraepithelial Lesion and Mimics
Dina R. Mody, MD and Ekene I. Okoye, MD
34 Atypical Squamous Cells of Undetermined Significance
Nikolaos Chantziantoniou, PhD, ART(CSMLS), CFIAC and Dina R. Mody, MD
36 Atypical Squamous Cells, Cannot Rule Out High-Grade Squamous Intraepithelial Lesion
Dina R. Mody, MD and Nikolaos Chantziantoniou, PhD, ART(CSMLS), CFIAC
38 Squamous Cell Carcinoma of Cervix, Variants and Mimics
Dina R. Mody, MD

46 Endocervical Adenocarcinoma In Situ, Variants and Mimics
Dina R. Mody, MD
52 Endocervical Adenocarcinoma, Variants and Mimics
Dina R. Mody, MD
56 Adenocarcinoma, Gastric Type
Dina R. Mody, MD
58 Endometrial Cancers: Usual Types, Variants, and Mimics
Ekene I. Okoye, MD and Dina R. Mody, MD
64 Atypical Glandular Cells: Endocervicals, Endometrials, and Glandulars, NOS
Dina R. Mody, MD
70 Endometrial Cells in Pap Test and Glandular Cells Status Post Hysterectomy
Dina R. Mody, MD and Ekene I. Okoye, MD

74  Extrauterine Carcinomas and Presentations in 
Cervicovaginal Cytology 
Dina R. Mody, MD 
76  Neuroendocrine Carcinoma of Cervix 
Dina R. Mody, MD 
78  Other Uncommon Malignancies in Cervicovaginal 
Cytology 
Dina R. Mody, MD 

84 HPV and Other Molecular Testing in Gynecologic Cytology
Michael J. Thrall, MD

90 Directly Sampled Endometrial Cytology
Yuko Sugiyama, MD, PhD, FIAC and Dina R. Mody, MD

96 Anal Cytology
Michael J. Thrall, MD

Part II: Exfoliative Cytopathology

Specimen Types in Respiratory Cytology and Adequacy Criteria
Michael J. Thrall, MD
102 Benign and Reactive Changes
Michael J. Thrall, MD
106 PneumocystisPneumonia and Mimics
Michael J. Thrall, MD
108 Fungal Organisms in Respiratory Cytology
Michael J. Thrall, MD
Parasitic Organisms in Respiratory Cytology
Michael J. Thrall, MD
112 Viral Infections (Cytomegalovirus, Herpesvirus, and Others)
Michael J. Thrall, MD
114 Mycobacteria and Other Bacterial Infections
Michael J. Thrall, MD
116 Sarcoidosis and Other Immune-Related Conditions
Michael J. Thrall, MD
118 Pulmonary Alveolar Proteinosis and Mimics
Michael J. Thrall, MD
Miscellaneous Findings, Including Contaminants
Michael J. Thrall, MD
122 Adenocarcinoma
Michael J. Thrall, MD
126 Squamous Cell Carcinoma
Michael J. Thrall, MD
128 Small Cell Carcinoma
Michael J. Thrall, MD
Large Cell Neuroendocrine Carcinoma
Michael J. Thrall, MD
132 Carcinoid and Atypical Carcinoid
Michael J. Thrall, MD
134 Rare Benign and Low Malignant Potential Tumors
Michael J. Thrall, MD
136 Rare Malignant Tumors
Michael J. Thrall, MD
138 NUT Carcinoma
Michael J. Thrall, MD
139 SMARCA4-Deficient Undifferentiated Tumor
Michael J. Thrall, MD
Pulmonary Lymphoma
Michael J. Thrall, MD
142 Pulmonary Metastasis
Michael J. Thrall, MD

146 Specimen Types in Gastrointestinal Cytology and Normal Cellular Components
Blythe K. Gorman, MD
148 Parasitic Infections
Blythe K. Gorman, MD
Viral Infections
Blythe K. Gorman, MD
152 Esophagitis and Barrett Esophagus
Blythe K. Gorman, MD
154 Esophageal Adenocarcinoma
Blythe K. Gorman, MD
156 Esophageal Squamous Cell Carcinoma
Blythe K. Gorman, MD
158 Gastritis and Intestinal Metaplasia
Blythe K. Gorman, MD
Gastric Adenocarcinoma
Blythe K. Gorman, MD
162 Gastric Lymphoma
Blythe K. Gorman, MD
164 Ampulla/Bile Duct/Pancreatic Duct Reactive Changes
Blythe K. Gorman, MD
166 Ampulla/Bile Duct/Pancreatic Duct Adenocarcinoma
Blythe K. Gorman, MD
168 Colorectal Adenoma/Carcinoma
Blythe K. Gorman, MD
Neuroendocrine Tumor/Carcinoma
Blythe K. Gorman, MD
172 Spindle Cell Neoplasms of Gastrointestinal Tract, Including Gastrointestinal Stromal Tumors
Blythe K. Gorman, MD

176 Normal Cerebrospinal Fluid and Contamination by Normal Elements
Hidehiro Takei, MD
Infectious Meningitis
Hidehiro Takei, MD
182 Aseptic and Mollaret Meningitis
Hidehiro Takei, MD
184 Subarachnoid Hemorrhage
Hidehiro Takei, MD
186 Neurodegenerative Diseases
Hidehiro Takei, MD
188 Primary Brain Tumors
Hidehiro Takei, MD
Leukemia and Lymphoma
Hidehiro Takei, MD
192 Metastasis in Cerebrospinal Fluid
Hidehiro Takei, MD

196 Normal Cellular Components, Reactive Mesothelial Proliferations, and Reporting Terminology
Donna M. Coffey, MD and Michael J. Thrall, MD
Infectious Conditions
Donna M. Coffey, MD and Michael J. Thrall, MD
202 Autoimmune Diseases
Donna M. Coffey, MD and Michael J. Thrall, MD
204 Malignant Effusion, Mesothelioma
208 Malignant Effusion, Carcinomas 212 Malignant Effusion, Sarcomas

Donna M. Coffey, MD, Nour Sneige, MD, and Michael J. Thrall, MD

214 Lymphoid Effusions and Lymphomas
Donna M. Coffey, MD and Michael J. Thrall, MD

216 Primary Effusion Lymphoma
John M. Stewart, MD, PhD and Michael J. Thrall, MD

218 Endometriosis and Endosalpingiosis
Donna M. Coffey, MD, Nour Sneige, MD, and Michael J. Thrall, MD

220 Ovarian Neoplasms
Donna M. Coffey, MD and Michael J. Thrall, MD

222 Immunocytochemistry, Histochemistry, and Other Ancillary Techniques
Donna M. Coffey, MD and Michael J. Thrall, MD

228 Normal Urinary Cytology, Specimen Types, and Reporting Terminology
Michael J. Thrall, MD and Rose Anton, MD

232 Ileal Conduit Specimens
Rose Anton, MD and Michael J. Thrall, MD

234 Noninfectious Benign Conditions
Rose Anton, MD and Michael J. Thrall, MD

236 Infectious Benign Conditions
Rose Anton, MD and Michael J. Thrall, MD

238 Reactive Urothelial Changes
Rose Anton, MD and Michael J. Thrall, MD

240 Low-Grade Urothelial Lesions
Rose Anton, MD and Michael J. Thrall, MD

241 Atypical Urothelial Cells
Michael J. Thrall, MD

242 High-Grade Urothelial Dysplasia/Carcinoma/Carcinoma In Situ
Rose Anton, MD and Michael J. Thrall, MD

244 Squamous Cell Carcinoma of Urinary Bladder
Rose Anton, MD, Nour Sneige, MD, and Michael J. Thrall, MD

246 Adenocarcinoma of Urinary Bladder
Rose Anton, MD, Nour Sneige, MD, and Michael J. Thrall, MD

248 Other Malignancies in Urinary Cytology
Rose Anton, MD, Nour Sneige, MD, and Michael J. Thrall, MD

250 Renal Pelvic Cytology
Blythe K. Gorman, MD and Michael J. Thrall, MD

252 Ancillary Testing, UroVysion, and Others
Gene Landon, MD, Nancy P. Caraway, MD, and Michael J. Thrall, MD

Part III: Fine-Needle Aspiration, Superficial

256 Superficial Aspiration Technique
Rose Anton, MD and Dina R. Mody, MD

260 Ultrasound-Guided Thyroid Fine-Needle Aspiration
Paula J. Woodward, MD
266 Thyroid Fine-Needle Aspiration Reporting Terminology and Specimen Adequacy
Dina R. Mody, MD
268 Adenomatous (Benign Follicular) Nodule
Mojgan Amrikachi, MD and Dina R. Mody, MD
270 Chronic Lymphocytic/Hashimoto Thyroiditis
Mojgan Amrikachi, MD and Dina R. Mody, MD
272 Granulomatous Thyroiditis
Mojgan Amrikachi, MD and Dina R. Mody, MD
274 Graves Disease/Diffuse Toxic Goiter
Mukul K. Divatia, MD and Dina R. Mody, MD
275 Pigmented Thyroid Lesions and Crystals
Mukul K. Divatia, MD and Dina R. Mody, MD
276 Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance
Dina R. Mody, MD
280 Follicular Neoplasm/Suspicious for a Follicular Neoplasm
Dina R. Mody, MD
284 Follicular Neoplasm, Oncocytic (Hürthle Cell) Type
Mojgan Amrikachi, MD and Dina R. Mody, MD
286 Papillary Thyroid Carcinoma, Classic Subtype
Mojgan Amrikachi, MD and Dina R. Mody, MD
290 Papillary Thyroid Carcinoma Subtypes
Mojgan Amrikachi, MD and Dina R. Mody, MD
298 Medullary Thyroid Carcinoma
Mojgan Amrikachi, MD and Dina R. Mody, MD
302 Poorly Differentiated Thyroid Carcinoma
Susan L. Haley, MD and Dina R. Mody, MD
304 Anaplastic Thyroid Carcinoma
Susan L. Haley, MD and Dina R. Mody, MD
306 Thyroid Lymphoma
Susan L. Haley, MD and Dina R. Mody, MD
308 Metastatic Carcinoma to Thyroid
Susan L. Haley, MD and Dina R. Mody, MD
310 Other Nonneoplastic and Neoplastic Thyroid Lesions Encountered on Thyroid FNA
Mojgan Amrikachi, MD and Dina R. Mody, MD

318 Parathyroid Cyst, Adenoma, and Carcinoma Susan L. Haley, MD, Rose Anton, MD, and Dina R. Mody, MD

OVERVIEW
324 Lymph Node Aspiration: Indications, Techniques, and Reporting
Rose Anton, MD and Dina R. Mody, MD
326 FNA Sample Prep and Triage in Evaluating Suspected Lymphoma
John M. Stewart, MD, PhD and Savitri Krishnamurthy, MD

BENIGN, INFECTIOUS, AND REACTIVE HYPERPLASIA
328 Inflammatory and Reactive Lymphoid Hyperplasia
Rose Anton, MD and Savitri Krishnamurthy, MD

330 Granulomatous Lymphadenitis, Infectious and Sarcoid
Rose Anton, MD and Savitri Krishnamurthy, MD

334 Rosai-Dorfman Disease
Rose Anton, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD

METASTATIC MALIGNANCIES
336 Metastatic Malignancies (Carcinoma, Melanoma)
Rose Anton, MD and Dina R. Mody, MD

338 HPV-Positive Head and Neck Squamous Cell Carcinoma
Mary R. Schwartz, MD and Dina R. Mody, MD

NODAL B-CELL LYMPHOMA
342 Small Lymphocytic Lymphoma Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD
344 Lymphoplasmacytic Lymphoma Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD
346 Mantle Cell Lymphoma Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD
348 Nodal Marginal Zone Lymphoma Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD
350 Follicular Lymphoma Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD
352 Burkitt Lymphoma Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD
354 Large B-Cell Lymphoma Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD
EXTRANODAL B-CELL LYMPHOMA
356 Plasmacytoma Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD
358 Mediastinal Large B-Cell Lymphoma Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD
360 Plasmablastic Lymphoma John M. Stewart, MD, PhD, Nancy P. Caraway, MD, and Savitri Krishnamurthy, MD
T-CELL LYMPHOMA
362 Peripheral T-Cell Lymphoma Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD
364 Mycosis Fungoides Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD
366 Angioimmunoblastic Lymphoma Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD
368 ALK(+) Anaplastic Large Cell Lymphoma Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD
370 T-Cell Lymphoblastic Lymphoma Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD
HODGKIN LYMPHOMA
372 Nodular Lymphocyte-Predominant Hodgkin Lymphoma
Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD

374 Classic Hodgkin Lymphoma
Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD

OVERVIEW
378 Approach to Interpretation of Salivary Gland Aspiration Biopsies and Reporting Terminology (Milan System) Dina R. Mody, MD
BENIGN LESIONS
382 Normal Salivary Gland and Sialadenitis on Aspiration
Rose Anton, MD and Dina R. Mody, MD

384 Cysts
Rose Anton, MD and Dina R. Mody, MD

386 Pleomorphic Adenoma
Rose Anton, MD and Dina R. Mody, MD

388 Warthin Tumor
Rose Anton, MD and Dina R. Mody, MD

390 Myoepithelioma
Rose Anton, MD and Dina R. Mody, MD

391 Oncocytoma, Salivary Gland
Dina R. Mody, MD

MALIGNANT NEOPLASMS
392 Adenoid Cystic Carcinoma
Rose Anton, MD and Dina R. Mody, MD

394 Acinic Cell Carcinoma
Rose Anton, MD and Dina R. Mody, MD

396 Mucoepidermoid Carcinoma
Rose Anton, MD and Dina R. Mody, MD

398 Basaloid Neoplasms, Benign and Malignant
Hidehiro Takei, MD and Dina R. Mody, MD

400 Carcinoma Ex Pleomorphic Adenoma
Hidehiro Takei, MD

402 Adenocarcinoma, NOS 404 Polymorphous Adenocarcinoma

Hidehiro Takei, MD and Dina R. Mody, MD
406 Salivary Duct Carcinoma
Hidehiro Takei, MD and Dina R. Mody, MD
408 Secretory Carcinoma
Michael J. Thrall, MD
410 Myoepithelial Carcinoma
Shubhada Kane, MD and Michael J. Thrall, MD
411 Cribriform Adenocarcinoma
Shubhada Kane, MD and Michael J. Thrall, MD
412 Metastatic Carcinoma
Hidehiro Takei, MD
414 Primary and Metastatic Nonepithelial Tumors
Dina R. Mody, MD and Hidehiro Takei, MD

OVERVIEW

418 Role of Fine-Needle Aspiration of Breast, Techniques and Triple Test
Savitri Krishnamurthy, MD
BENIGN BREAST LESIONS
420 Inflammatory and Granulomatous Conditions
Savitri Krishnamurthy, MD
422 Fat Necrosis
Savitri Krishnamurthy, MD

424 Nonproliferative and Proliferative Changes in Breast
Savitri Krishnamurthy, MD
428 Radial Scar/Complex Sclerosing Lesion
Savitri Krishnamurthy, MD
430 Gynecomastia
Savitri Krishnamurthy, MD
432 Mucocele-Like Lesion
Savitri Krishnamurthy, MD
BENIGN NEOPLASMS
434 Fibroadenoma
Savitri Krishnamurthy, MD
438 Granular Cell Tumor of Breast
Savitri Krishnamurthy, MD
440 Papillary Neoplasms
Savitri Krishnamurthy, MD
446 Myofibroblastoma, Mammary
Savitri Krishnamurthy, MD
MALIGNANT NEOPLASMS

448 Ductal Carcinoma and Variants of Invasive Mammary Carcinoma
Savitri Krishnamurthy, MD
456 Lobular Carcinoma
Savitri Krishnamurthy, MD
458 Phyllodes Tumor
Savitri Krishnamurthy, MD
460 Angiosarcoma and Other Sarcomas
Savitri Krishnamurthy, MD
464 Lymphomas and Metastatic Tumors
Savitri Krishnamurthy, MD
NIPPLE DISCHARGE
466 Cytology Specimens for Risk Assessment of Breast Cancer
Savitri Krishnamurthy, MD

470 Cutaneous and Adnexal Cytology
Mary R. Schwartz, MD and Dina R. Mody, MD

Part IV: Fine-Needle Aspiration, Deep Organs and Tissues

476 Techniques and Modalities of Deep Aspiration Biopsies
Paula J. Woodward, MD and Ashraf Thabet, MD

OVERVIEW
482 Anatomic Compartments and Constituent Tumors
Ming Guo, MD and Savitri Krishnamurthy, MD
NONNEOPLASTIC LESIONS
484 Mediastinal Cysts and Inflammatory Lesions
Ming Guo, MD and Savitri Krishnamurthy, MD
NEOPLASMS
486 Thymoma
Ming Guo, MD and Savitri Krishnamurthy, MD
488 Thymic Carcinoma
Ming Guo, MD and Savitri Krishnamurthy, MD
490 Germ Cell Tumors
Ming Guo, MD and Savitri Krishnamurthy, MD
492 Neurogenic Tumors
Ming Guo, MD and Savitri Krishnamurthy, MD
494 Metastatic Tumors of Mediastinum
Ming Guo, MD and Savitri Krishnamurthy, MD

OVERVIEW
498 Cytology of Normal Liver Elizabeth M. Jacobi, MD, Rose Anton, MD, and Michael J. Thrall, MD
500 Inflammatory and Infectious Conditions of Liver Elizabeth M. Jacobi, MD, Rose Anton, MD, and Michael J. Thrall, MD
BENIGN HEPATIC NEOPLASMS
502 Hepatocellular Adenoma Elizabeth M. Jacobi, MD, Rose Anton, MD, and Michael J. Thrall, MD

504 Focal Nodular Hyperplasia Elizabeth M. Jacobi, MD, Rose Anton, MD, and Michael J. Thrall, MD
506 Hemangioma, Liver Elizabeth M. Jacobi, MD, Rose Anton, MD, and Michael J. Thrall, MD
MALIGNANT NEOPLASMS
508 Hepatocellular Carcinoma Elizabeth M. Jacobi, MD, Rose Anton, MD, and Michael J. Thrall, MD
510 Hepatoblastoma Elizabeth M. Jacobi, MD, Rose Anton, MD, and Michael J. Thrall, MD
512 Liver Metastasis Elizabeth M. Jacobi, MD, Rose Anton, MD, and Michael J. Thrall, MD

OVERVIEW
516 Cytology of Normal Kidney
Yimin Ge, MD
BENIGN LESIONS AND NEOPLASMS
518 Renal Cysts
Yimin Ge, MD
520 Angiomyolipoma
Yimin Ge, MD
522 Oncocytoma, Kidney
Yimin Ge, MD
524 Metanephric Adenoma
Yimin Ge, MD and Jun Zhang, MD, MS
526 Metanephric Stromal Tumor
Yimin Ge, MD and Norma Quintanilla, MD
527 Xanthogranulomatous Pyelonephritis/Malakoplakia
Yimin Ge, MD
MALIGNANT NEOPLASMS
528 Clear Cell Renal Cell Carcinoma
Yimin Ge, MD
532 Papillary Renal Cell Carcinoma
Yimin Ge, MD
534 Clear Cell Papillary Renal Cell Carcinoma
Michael J. Thrall, MD
536 Chromophobe Renal Cell Carcinoma
Yimin Ge, MD
538 TFE3- andTFEB-Rearranged Renal Cell Carcinomas
Michael J. Thrall, MD
540 Collecting Duct Carcinoma
Yimin Ge, MD and Jun Zhang, MD, MS
541 Renal Medullary Carcinoma
Yimin Ge, MD
542 Mucinous Tubular and Spindle Cell Carcinoma of Kidney
Yimin Ge, MD
543 Carcinoid Tumor
Yimin Ge, MD
544 Primary Renal Sarcomas in Adults
Yimin Ge, MD and Jun Zhang, MD, MS
545 Renal Lymphomas
Yimin Ge, MD and Jun Zhang, MD, MS
546 Nephroblastoma (Wilms Tumor) Yimin Ge, MD, Jun Zhang, MD, MS, and Norma Quintanilla, MD
548 Clear Cell Sarcoma of Kidney
Yimin Ge, MD and Norma Quintanilla, MD
550 Congenital Mesoblastic Nephroma
Yimin Ge, MD and Norma Quintanilla, MD
552 Rhabdoid Tumor of Kidney
Yimin Ge, MD and Norma Quintanilla, MD
553 Metastatic Tumors to Kidney
Yimin Ge, MD
TUMORS OF RENAL PELVIS
554 Urothelial Carcinoma
Yimin Ge, MD

OVERVIEW
558 Cytology of Normal Adrenal Gland
Yimin Ge, MD
ADRENAL CORTICAL LESIONS
560 Adrenal Cortical Adenoma
Yimin Ge, MD
562 Adrenal Cortical Carcinoma
Yimin Ge, MD
564 Metastatic Tumors to Adrenal Gland
Yimin Ge, MD
ADRENAL MEDULLARY LESIONS
566 Pheochromocytoma
Yimin Ge, MD

OVERVIEW
570 Cytology of Normal Pancreas
Uma Kundu, MD and Dina R. Mody, MD
572 Pancreaticobiliary Cytology Reporting Terminology, Cyst Evaluation
Dina R. Mody, MD and Mary R. Schwartz, MD
NONNEOPLASTIC LESIONS
574 Pancreatitis
Uma Kundu, MD and Dina R. Mody, MD
576 Lymphoepithelial Cyst of Pancreas
Dina R. Mody, MD
577 Intra- and Peripancreatic Splenules
Dina R. Mody, MD
578 Serous Microcystic Adenoma
Uma Kundu, MD and Savitri Krishnamurthy, MD

Mucinous Cystic Neoplasm
Uma Kundu, MD and Savitri Krishnamurthy, MD
582 Intraductal Papillary Mucinous Neoplasm
Uma Kundu, MD and Savitri Krishnamurthy, MD
584 Solid Pseudopapillary Neoplasm
Gene Landon, MD and Savitri Krishnamurthy, MD
586 Pancreatic Neuroendocrine Tumor
Gene Landon, MD and Savitri Krishnamurthy, MD
588 Pancreatic Ductal Adenocarcinoma
Gene Landon, MD and Savitri Krishnamurthy, MD
Unusual Variants of Ductal Carcinoma
Savitri Krishnamurthy, MD
594 Acinar Cell Carcinoma
Savitri Krishnamurthy, MD
596 Lymphoma and Secondary Tumors of Pancreas
Savitri Krishnamurthy, MD

OVERVIEW
Approach to Cytologic/Small Biopsy Diagnosis of Primary Bone Tumors
Dina R. Mody, MD
NEOPLASMS
602 Chondromas of Bone and Soft Tissue
Mukul K. Divatia, MD and Dina R. Mody, MD
604 Chondroblastoma
Dina R. Mody, MD
606 Giant Cell Tumor
Dina R. Mody, MD
608 Osteoblastoma
Dina R. Mody, MD
Adamantinoma
Dina R. Mody, MD
612 Langerhans Cell Histiocytosis
Dina R. Mody, MD
614 Chordoma
Dina R. Mody, MD
616 Osteosarcoma
Savitri Krishnamurthy, MD
Chondrosarcoma
Savitri Krishnamurthy, MD
624 Ewing Sarcoma
Savitri Krishnamurthy, MD
628 Bone Lymphoma
Dina R. Mody, MD
Metastatic Tumors of Bone
Dina R. Mody, MD

OVERVIEW
634 Approach to Cytologic/Small Biopsy Diagnosis of Primary Soft Tissue Lesions
Dina R. Mody, MD
ADIPOCYTIC TUMORS
636 Benign Adipose Tissue Tumors
Uma Kundu, MD and Savitri Krishnamurthy, MD
638 Liposarcoma
Uma Kundu, MD and Savitri Krishnamurthy, MD
FIBROBLASTIC/MYOFIBROBLASTIC LESIONS
642 Fibrosarcoma
Uma Kundu, MD and Savitri Krishnamurthy, MD
644 Myofibroblastoma
Savitri Krishnamurthy, MD
646 Low-Grade Myofibroblastic Sarcoma
Uma Kundu, MD and Savitri Krishnamurthy, MD
FIBROHISTIOCYTIC TUMORS
648 Giant Cell Tumor of Tendon Sheath
Uma Kundu, MD and Savitri Krishnamurthy, MD
650 Undifferentiated Pleomorphic Sarcoma
Uma Kundu, MD and Savitri Krishnamurthy, MD
TUMORS OF MUSCLE ORIGIN
652 Smooth Muscle Tumors
Gene Landon, MD and Savitri Krishnamurthy, MD
654 Skeletal Muscle Tumors
Gene Landon, MD and Savitri Krishnamurthy, MD
VASCULAR TUMORS
658 Hemangioma, Soft Tissue
Gene Landon, MD and Michael J. Thrall, MD
660 Epithelioid Hemangioendothelioma
Gene Landon, MD and Michael J. Thrall, MD
662 Angiosarcoma
Gene Landon, MD and Savitri Krishnamurthy, MD
OTHER TUMORS
664 Other Reactive and Neoplastic Soft Tissue Entities
Dina R. Mody, MD
666 Mesenchymal Chondrosarcoma
Dina R. Mody, MD
667 Solitary Fibrous Tumor
Dina R. Mody, MD
668 Intramuscular Myxoma
Gene Landon, MD and Savitri Krishnamurthy, MD
670 Synovial Sarcoma
Gene Landon, MD and Savitri Krishnamurthy, MD
672 Epithelioid Sarcoma
Gene Landon, MD and Savitri Krishnamurthy, MD
674 Alveolar Soft Part Sarcoma
Uma Kundu, MD and Savitri Krishnamurthy, MD
676 Clear Cell Sarcoma of Soft Tissue
Uma Kundu, MD and Savitri Krishnamurthy, MD
678 Desmoplastic Small Round Cell Tumor
Uma Kundu, MD and Savitri Krishnamurthy, MD

682 Approach to Ophthalmic Cytology
Patricia Chévez-Barrios, MD
686 Ophthalmic Cytopathology, Infectious
Patricia Chévez-Barrios, MD
690 Ophthalmic Cytopathology, Neoplastic
Patricia Chévez-Barrios, MD
696 Neuropathology Squash Preparations, Infectious
Andreana L. Rivera, MD, Suzanne Z. Powell, MD, and Hidehiro Takei, MD
700 Neuropathology Squash Preparations, Glial Neoplasms
Suzanne Z. Powell, MD, Andreana L. Rivera, MD, and Hidehiro Takei, MD
704 Neuropathology Squash Preparations, Nonglial Neoplasms
Andreana L. Rivera, MD, Suzanne Z. Powell, MD, and Hidehiro Takei, MD

Part V: Management and Ancillary Testing

710 Cytopreparatory Techniques and Instrumentation in Nongynecologic Cytology
Debora A. Smith, CT(ASCP) and Dina R. Mody, MD
716 Quality Improvement and Laboratory Management for Cytopathology
Debora A. Smith, CT(ASCP) and Dina R. Mody, MD