Table of Contents
Current TOC; final to be done in summer 2019:
Section 1 STRUCTURAL AND MOLECULAR BASES OF ION CHANNEL FUNCTION
1. Voltage-gated sodium channels and electrical excitability of the heart
2. Voltage-gated calcium
3. Voltage-gated potassium channels
4. Structural and molecular bases of cardiac inward rectifier potassium channel function
5. Mammalian calcium pumps in health and disease
6. Structural and molecular bases of sarcoplasmic reticulum ion channel function
7. Organellar ion channels and transporters
8. Molecular organization, gating, and function of connexin-based gap junction channels and hemichannels
Section 2 BIOPHYSICS OF CARDIAC ION CHANNEL FUNCTION
9. Structure-function relations of heterotrimetric complexes of sodium channel a and ß subunits
10. Regulation of cardiac calcium channels
11. Inhibition of phosphoinositide 3-kinase and acquired long QT syndrome
12. Structural determinants and biophysical properties of hERG1 channel gating
13. Molecular regulation of cardiac inward rectifier potassium channels by pharmacologic agents
14. Cardiac stretch-activated channels and mechano-electric coupling
15. Biophysical properties of gap junctions
16. Excitation-contraction coupling
Section 3 INTERMOLECULAR INTERACTIONS AND CARDIOMYOCYTE ELECTRICAL FUNCTION
17. Ion channel trafficking in the heart
18. Microdomain interactions of macromolecular complexes and regulation of the sodium channel nav1.5
19. Fibroblast growth factor homologous factors modulate cardiac calcium channels
20. Macromolecular complexes and cardiac potassium channels
21. Reciprocity of cardiac sodium and potassium channels in the control of excitability and arrhythmias
22. The intercalated disc: A molecular network that integrates electrical coupling, intercellular adhesion an
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